Serena Williams' bid for a fourth Grand Slam title in a row - the self-titled 'Serena Slam' - will begin against Margarita Gasparyan of Russia and could include a fourth-round clash with her sister Venus.
See the full women's singles draw
Venus and Serena are both five-time singles champions at Wimbledon, and have collected five women's doubles titles together.
Serena leads their Wimbledon head-to-head 3-2 and the last time the sisters played at SW19 outside of a final was in the 2000 semi-finals.
Serena, making her 16th appearance at The Championships, takes on world No.113 Gasparyan in the top half of the draw and could meet Ana Ivanovic in the quarter-finals and 2004 champion Maria Sharapova in the last four.
Sharapova will have to contend with the home crowd in her opening match after being drawn to face Eastbourne quarter-finalist Johanna Konta.
Over to the bottom half of the draw and reigning champion Petra Kvitova will open her title defence against Kiki Bertens on Tuesday while third seed Simona Halep - Kvitova's potential semi-final opponent - is drawn against Slovakian Jana Cepelova in the first round.
Fifth seed Caroline Wozniacki opens her account with a tricky match against Saisai Zheng, and the powerful German Angelique Kerber is a possible fourth-round contest.
Heather Watson leads the way for the British contingent, with a first-round contest with world No.33 Caroline Garcia, meanwhile the returning Laura Robson opens her Wimbledon campaign up against Evgeniya Rodina.
Should Robson win her opening two matches, she could face Kvitova in the third round for the chance to repeat her 2013 victory at the Australian Open.
Fresh from her maiden Grand Slam final at Roland Garros, Lucie Safarova will take on the challenge of American Alison Riske, who usually excels on grass.
Having defeated Sharapova in Paris, Safarova might have the chance to repeat the feat in the quarter-finals.
An intriguing clash between 17-year-old Nottingham champion Ana Konjuh and Alize Cornet, who defeated Serena Williams last year, will be a highlight of the opening matches.
Last year’s finalist Eugenie Bouchard will hope to rediscover her form in the first round when taking on China’s Ying-Ying Duan. The Canadian is lined-up for a possible third round clash with Amercian Madison Keys and could see a repeat of the 2014 final in the last eight.
Elsewhere the rejuvenated Sloane Stephens will play world No.28 Barbora Strycova and the rising Swiss star Belinda Bencic will have to prevail against grass court specialist Tsvetana Pironkova.
